德诺苏马布的停用:COVID-19大流行及以后的情况
1Department of Clinical, Internal, Anaesthesiologic and Cardiovascular Sciences, "Sapienza" University of Rome.
JBMR plus
|June 3, 2024
概括
随着COVID-19大流行,慢性病患者的德诺苏马布治疗中断了. 编程策略对于在紧急情况之外管理停止使用denosumab至关重要,以防止不良结果.
科学领域:
- 骨质疏松症和骨质新陈代谢
- 药理学和治疗学 药理学和治疗学
- 公共卫生和流行病学
背景情况:
- COVID-19大流行严重扰乱了全球医疗保健系统,特别影响了慢性病患者.
- 研究表明,在疫情爆发期间,及时给予德诺苏马布的治疗率最初有所下降.
- 除了与流行病相关的紧急情况之外,在各种临床场景中也可能发生德诺苏马布的停用.
研究的目的:
- 为了突出COVID-19大流行对德诺苏马布治疗的影响.
- 强调需要战略管理停止使用登苏马布的必要性.
- 概述优化患者护理和最大限度地减少与治疗中断相关的风险的方法.
主要方法:
- 审查现有的文学在denosumab治疗中断.
- 临床情景的分析,导致停止使用德诺苏马布.
- 开发一个管理治疗中断的框架.
主要成果:
- 这场大流行导致了denosumab治疗计划的直接中断.
- 停止治疗的非流行病相关原因也需要谨慎管理.
- 积极主动的策略对于护理的连续性至关重要.
结论:
- 有效的管理策略对于denosumab治疗至关重要,特别是在医疗保健危机期间.
- 积极的规划可以减轻与停止使用登苏马布相关的风险.
- 确保一致的患者护理需要适应性治疗方案.
相关概念视频
Desensitization and Tachyphylaxis
1.7K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.7K
Pharmacovigilance
825
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
825
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics
444
All neuromuscular blocking agents are injected intravenously because they are poorly absorbed from the GI tract. Rapid onset is achieved with intravenous administration, although absorption is also adequate from an intramuscular injection. Since these agents are highly ionized, they do not readily penetrate cell membranes or cross the blood-brain barrier.
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
444
Vaccinations
44.4K
Overview
44.4K
Discharge Summary Forms
751
The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
751


