测试光学一致性断层扫描的可靠性,以测量表皮厚度,并区分和非皮肤的可靠性
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Molly E Baumann1,2, Nina Rossa Haddad3, Alyssa Salazar2,4
1Research and Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Defense Health Agency, Falls Church, Virginia, USA.
概括
光学连贯断层扫描 (OCT) 显示飞皮肤比非飞皮肤显著更厚,包括残余四肢皮肤. 这种成像技术可以区分皮肤类型,这对于假肢使用至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 假肢手术 假肢手术是一门专业.
背景情况:
- 假肢设备可以导致肢体损失的个体的皮肤分解.
- 剩余的四肢皮肤 (nonvolar) 没有适应承重,不像手掌植物 (volar) 皮肤.
- 在评估皮肤弹性治疗之前,建立规范性数据和可靠的结果指标至关重要.
研究的目的:
- 用光学连贯断层扫描 (OCT) 来描述飞和非飞皮肤表皮厚度.
- 检查OCT在评估表皮厚度方面的可靠性.
- 为了区分飞和非飞区域之间的皮肤厚度,包括残余四肢.
主要方法:
- 在两个时间点从33名志愿者 (包括6名失去四肢) 收集了OCT图像.
- 通过追踪OCT图像从 volar (手掌),后大腿和残余四肢位置来量化表皮厚度.
- 使用类内相关系数 (ICC) 评估评价者之间的可靠性.
主要成果:
- 与大腿后部 (89.8 ± 18.1 μm) 和残余四肢皮肤 (93.4 ± 27.4 μm) 相比,皮 (手掌) 的表皮厚度显著增加 (265.1 ± 50.9 μm).
- 观察到飞皮肤的高间值可靠性 (ICC:0.887-0.956).
- 对于非体皮肤 (大腿和残肢) 发现了较低的inter-rater可靠性 (ICC:0.211-0.391),尽管它通过一致的显示技术得到了改善.
结论:
- 光学连贯断层扫描可以有效地根据表皮厚度区分飞和非飞皮肤类型.
- 虽然OCT在分化皮肤方面表现有前途,但识别皮肤-表皮连接的挑战会影响非发性皮肤的可靠性.
- 进一步的研究可能会完善OCT方法,以更可靠地评估假肢使用者的非毛皮.
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