接空间的功能重新配置在个体有风险的酒精使用障碍障碍
Mahdi Moghaddam1,2, Mario Dzemidzic3,4, Daniel Guerrero1,2
1School of Industrial Engineering, Purdue University, West-Lafayette, IN, USA.
ArXiv
|June 3, 2024
概括
在任务转换期间的大脑功能重构在患有酒精使用障碍 (AUD) 风险的个体中不同. 酒精使用障碍的家族史和最近的饮酒影响了这些动态的大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 数学建模的数学建模
背景情况:
- 人类大脑功能动态地适应环境刺激.
- 在任务参与和脱离过程中描述大脑功能重新配置至关重要,但研究不足.
- 了解这些动态对于识别酒精使用障碍 (AUD) 的神经生物学风险因素很重要.
研究的目的:
- 开发和应用一个数学框架来量化在任务转换期间的大脑功能重构.
- 调查酒精使用障碍 (AUD) 风险因素,特别是家庭酒精使用障碍 (FHA) 史和最近的饮酒对功能重构的影响.
- 为了比较患有AUD风险的个体的功能重新配置模式.
主要方法:
- 开发了一个使用触点空间投影 (里曼的几何绘图技术) 的原理数学框架.
- 54名参与者的功能连接体 (FC) 被转化为触点FC.
- 触角-FCs的相关距离被用于量化功能重新配置,并使用多线性回归模型进行分析.
主要成果:
- 参与和脱离功能重新配置与FHA和最近的饮酒有显著的关联.
- 参与停止信号任务 (SST) 显示功能重新配置和最近饮酒之间存在负相关性.
- 脱离SST显示了功能重新配置和FHA之间的负相关性.
结论:
- 触点-FCs有效地表征了任务诱导的功能重新配置.
- 在任务转换期间的功能重新配置明显与AUD风险有关.
- 这些发现突出了与AUD风险因素相关的潜在神经生物学标志物.
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