阴道微环境对人类乳头瘤病毒感染的免疫调节作用
Lingyan Sun1, Li Li1, Wenxin Xu1
1Department of Obstetrics and Gynecology Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China.
Galen medical journal
|June 3, 2024
概括
健康的阴道环境对于预防高风险的人类乳头瘤病毒 (hr-HPV) 感染至关重要. 阴道微生物组的不平衡,如酵母和加德内拉阴道菌的增加,与更高的h-HPV率和宫病变有关.
科学领域:
- 妇科 妇科医生 妇科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 阴道微生物群和微环境在免疫功能中发挥作用.
- 人类乳头瘤病毒 (HPV) 感染易感性受到阴道微环境的影响.
- 了解这种联系是管理HPV和相关的宫疾病的关键.
研究的目的:
- 研究阴道微环境与高风险HPV感染率 (hr-HPV) 之间的联系.
- 为了确定与hr-HPV状态相关的阴道中的特定微生物和生化标志物.
主要方法:
- 一项涉及512名女性的横截面研究,按hr-HPV阳性 (n=212) 和阴性 (n=300) 状态分类.
- 阴道样本对酵母,Gardnerella vaginalis,Lactobacillus acidophilus,pH和酶活性 (catalase,proline aminopeptidase,白细胞酶) 的分析.
- 阴道样品的组织病理学检查,以评估宫病变.
主要成果:
- 患有 hr-HPV 阳性感染的女性的酵母和G. vaginalis 发病率显著更高,L. acidophilus 水平更低 (P<0.001).
- 组织病理学显示,在 hr-HPV 阳性组中,宫内皮质瘤 (CIN) I-III 级和宫癌的发病率较高.
- 在特定的阴道微环境参数和hr-HPV状态之间发现了显著的相关性.
结论:
- 阴道微环境与 hr-HPV 感染有显著的相关性.
- 阴道微生物组和微环境的改变是高度子宫病变的危险因素.
- 保持健康的阴道环境对于预防与HPV相关的宫疾病可能很重要.
相关概念视频
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Immune Response Against Viral Pathogens
776
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
776
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K


