淋巴系统中的流体动力学和白细胞过境
Huabing Li1, Jingjing Zhang1, Timothy P Padera2
1Department of Material Science and Technology, Guilin University of Electronic Technology, Guilin 541004, China.
PNAS nexus
|June 3, 2024
概括
淋巴血管中的细胞运动是复杂的. 这项研究表明,收缩的血管壁和重力显著影响细胞速度和变形,特别是在门附近.
科学领域:
- 生物物理学的生物物理.
- 生理学 生理学 生理学
- 计算生物学 计算生物学
背景情况:
- 淋巴系统对于液体平衡,免疫反应和癌症转移至关重要.
- 了解淋巴血管内的细胞运输对于各种生理和病理过程至关重要.
研究的目的:
- 用计算模型研究收缩的淋巴血管中的细胞运动.
- 为了比较短暂的流动动力学与淋巴血管中的稳定流动.
- 分析血管收缩,门和重力对细胞动态的影响.
主要方法:
- 开发了一个基于博尔茨曼的2D格子计算模型.
- 在收缩的淋巴血管内运输的模拟细胞,带有双叶式门.
- 嵌入自主血管壁收缩受和氧化水平调节.
- 分析了船舶定向对重力的影响.
主要成果:
- 细胞在活跃的血管收缩过程中移动的速度快于平均流体速度.
- 流体力会在符合规定的细胞中引发显著的变形,特别是在门附近.
- 船舶与重力相对的方向通过影响收缩动力学来调节细胞运动.
- 引力的影响即使在中性浮动细胞中也持续存在.
结论:
- 淋巴血管中的细胞运动受到短暂的,由收缩驱动的流动的显著影响.
- 门附近的复杂流量环境在细胞运输和变形中发挥着关键作用.
- 计算机建模为淋巴细胞运输的生物力学提供了宝贵的见解.
相关概念视频
Laminar and Turbulent Flow
8.5K
Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the...
8.5K
Capillary Exchange
4.2K
The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
4.2K
Structure and Function of Leukocytes
2.0K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
2.0K
Fluid Movement Between Compartments
508
The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
508
Laminar Flow
1.0K
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
1.0K
Functions of the Lymphatic and Immune System
3.0K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
3.0K


