基因风险的代际传播 过度活跃和注意力不集中. 直接的基因传播还是基因培养?
Ivan Voronin1, Isabelle Ouellet-Morin2, Amélie Petitclerc1
1École de psychologie Université Laval Québec Quebec Canada.
JCPP advances
|June 3, 2024
概括
ADHD的遗传因素和教育成就影响了儿童的过度活跃和注意力不集中. 代际传播主要是通过直接的遗传发生,而不是来自父母的环境影响.
科学领域:
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 具有很高的遗传性和代际传播.
- 基因代际传播通过直接遗传或遗传培养 (父母环境) 来发生.
- 这项研究调查了通过这些途径对儿童过度活动和注意力缺失的遗传贡献.
研究的目的:
- 评估直接遗传传染和遗传培养对儿童多动症症状的贡献.
- 检查多基因得分对ADHD (ADHD-PGS) 和教育成就 (EA-PGS) 在ADHD症状传播中的作用.
主要方法:
- 利用北克新生儿双胞胎研究中的415个家庭的数据.
- 通过家长和教师的报告评估孩子的过度活动和注意力缺失.
- 从双胞胎和父母基因型中计算ADHD-PGS和EA-PGS;开发了一种代际传播模型.
主要成果:
- ADHD-PGS解释了多达1.6%的ADHD症状变异.
- EA-PGS预测了ADHD症状,解释了小学高达5.5%的差异.
- 直接遗传是两种PGS的主要途径;遗传培养效应在很大程度上是无意义的.
结论:
- 对ADHD的遗传倾向和教育预测了儿童的ADHD症状.
- 这些特征的代际传播主要是通过直接的遗传.
- 开发的模型可以促进对遗传传染和培养的研究,并考虑分类交配.
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