胰岛素抵抗指数和亚临床动脉样硬化之间的关联:当代综述
Drake A Scott1, Cynthia Ponir1, Michael D Shapiro1
1Department of Internal Medicine, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USA.
American journal of preventive cardiology
|June 3, 2024
概括
胰岛素抵抗是动脉样硬化的一个独立风险因素. 甘油三糖指数 (TyG) 始终与动脉样硬化标志物相关,这表明其有可能用于早期检测和干预.
科学领域:
- 心血管医学 心血管医学
- 代谢综合征是代谢综合征的一种.
- 生物标志物研究 生物标志物研究
背景情况:
- 胰岛素抵抗独立地导致动脉样硬化发展.
- 早期识别有风险的个体对于预防策略至关重要.
- 将胰岛素抵抗标记与动脉样硬化标记联系起来,可以促进早期诊断.
研究的目的:
- 审查有关胰岛素抵抗标志物和动脉样硬化标志物之间的相关性证据.
- 确定可靠的生物标志物,用于早期检测动脉样硬化.
- 探索胰岛素抵抗指数在心血管风险评估中的临床有用性.
主要方法:
- 对检查胰岛素抵抗标志物的研究进行系统审查:血清甘油三 (TG),甘油三-葡萄糖指数 (TyG) 和恒温模型评估 (HOMA).
- 分析与动脉样硬化标志物的关联:冠状动脉分数 (CAC),动脉内脏介质厚度 (cIMT) 和脉冲波速度 (PWV).
主要成果:
- 泰格指数显示,在不同人群中,与CAC的相关性最为一致.
- 在肥胖个体和没有糖尿病的人群中,HOMA显示了潜在的关联.
- 血清TG与PWV有很强的相关性,而TyG也与PWV有显著的关联.
- 胰岛素抵抗标志物和cIMT之间的关联不一致,在正常体重的个体中有一些TyG的证据.
结论:
- 泰格指数成为与动脉样硬化的一致相关的标志物,易于从常规实验室计算.
- TyG有可能指导早期治疗干预,特别是在没有2型糖尿病 (T2DM) 的患者中.
- 对非糖尿病患者TyG升高的进一步研究可以为减少动脉样硬化进展的策略提供信息.
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