血管和口腔下粘膜纤维化前进的组织学等级之间的相关性与恶性病的可信作用:对持久冲突问题的系统审查
Deepak Pandiar1, Suvarna K Nair1, Ronell Bologna-Molina2
1Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Sultan Qaboos University medical journal
|June 3, 2024
概括
口腔下粘膜纤维化 (OSMF) 的血管性随着晚期降低,挑战了将增加血管形成与癌症发展联系在一起的理论. 这一发现影响了对OSMF进展和恶性瘤风险的理解.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 组织病理学 组织病理学
背景情况:
- 口腔膜纤维化 (OSMF) 是一种潜在的恶性疾病.
- 血管性和OSMF向恶性瘤的进展之间的关系正在争论中.
- 传统的概念表明,随着疾病的进展,血管性增加.
研究的目的:
- 在OSMF的组织学等级上量化血管性.
- 为了研究血管生成和OSMF恶性瘤之间的联系.
- 评估当前关于OSMF阶段血管性变化的文献.
主要方法:
- 在2022年12月之前,对已发表的文章进行系统审查.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 98篇文章的选,其中13篇被列入评估 (607个案例).
主要成果:
- 随着OSMF阶段的推进,包括平均血管密度在内的血管性在超过一半的评估研究中下降.
- 对于内皮细胞/μm2,平均血管面积百分比和平均血管面积观察到类似的趋势.
- 大多数包括在内的研究 (包括13项研究中的11项) 评估了平均血管密度.
结论:
- 该审查支持了血管性随着OSMF阶段的推进而减少的概念.
- 这一发现与暗示增加血管性促进致癌物质吸收和恶性病变的理论相矛盾.
- 减少血管性可能意味着OSMF进展到癌症的机制发生了变化.
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