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Updated: Jun 24, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

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合成和评估含有硫化物结构的新型ALK抑制剂

Han Yao1, Yuanyuan Ren1, Feng Wu1

  • 1School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou 510006 China lixsh@mail.sysu.edu.cn.

RSC advances
|June 3, 2024
PubMed
概括

新型硫化物化合物显示出强烈的抗癌活性,在临床前模型中抑制了形淋巴瘤激酶 (ALK) 和瘤生长. 化合物18d显示出作为新ALK抑制剂治疗的领先因素的巨大潜力.

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Preparation and Reactions of Sulfides02:26

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
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