Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Drug Distribution: Physiological Barriers01:23

Factors Affecting Drug Distribution: Physiological Barriers

196
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
196
Drug Delivery: Overview01:16

Drug Delivery: Overview

287
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
287
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

494
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
494
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

418
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
418
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

802
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
802

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Label-Free and High-Throughput Quantification of Nanoparticle-Cell Interactions at the Single-Cell Level with Flow Cytometry.

Analytical chemistry·2026
Same author

Promoting Self-Efficacy of Biomedical Engineering Undergraduate Students Using a Deliberately Designed Nanomedicine Workshop Series.

Biomedical engineering education·2026
Same author

YES Oklahoma: Building Pathways into Cancer Research and Public Health for Indigenous High School Students.

Journal of cancer education : the official journal of the American Association for Cancer Education·2026
Same author

Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides for Safe and Effective mRNA Delivery <i>In Vitro</i> and <i>In Vivo</i>.

ACS applied materials & interfaces·2026
Same author

The Predictive Synthesis of Monodisperse and Biocompatible Gold Nanoparticles.

ACS applied nano materials·2025
Same author

The Role of GPX Enzymes, Lipid Profiles, and Iron Accumulation in Necrotizing Enterocolitis.

International journal of molecular sciences·2025

相关实验视频

Updated: Jun 24, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K

探索和分析纳米颗粒的系统输送障碍

Lin Wang1, Skyler Quine1, Alex N Frickenstein1

  • 1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, Oklahoma, 73019, USA.

Advanced functional materials
|June 3, 2024
PubMed
概括

纳米颗粒去除血液的途径 (NBRP) 阻碍了纳米医药的输送. 表面化学,特别是生物-PEG修饰,显著改善体内血液循环,并减少器官积累,以提高纳米药物疗效.

关键词:
纳米医学是一种纳米医学.生物分销生物分销生物障碍物 生物障碍物文献调查 文献调查单核细胞系统 (MPS) 是一个单核细胞系统.纳米-生物相互作用.纳米颗粒去除血液的途径 (NBRP)纳米颗粒的交付方式药物动力学 药物动力学网膜内皮细胞系统 (RES)

更多相关视频

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.6K
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

7.5K

相关实验视频

Last Updated: Jun 24, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.6K
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

7.5K

科学领域:

  • 纳米医学是一种纳米医学.
  • 生物材料科学 生物材料科学
  • 药理动力学 药理动力学

背景情况:

  • 有效的体内输送对于纳米药物的有效性至关重要.
  • 系统管理的纳米颗粒面临生物障碍,称为纳米颗粒血液去除通路 (NBRP).
  • 了解NBRP是优化纳米医药设计和性能的关键.

研究的目的:

  • 定义和描述纳米颗粒去除血液的途径 (NBRP).
  • 审查在纳米医学中减轻NBRP相互作用的策略.
  • 分析关于纳米粒子行为的临床前数据并确定设计趋势.

主要方法:

  • 临床前纳米医学文献的系统审查 (2011-2021年).
  • 对纳米粒子血液循环和器官生物分布数据的分析.
  • 对纳米粒子设计和表面修饰对NBRP的影响的评估.

主要成果:

  • 纳米粒子表面化学是体内行为的一个关键决定因素.
  • 组合生物-PEG表面修饰增强了血液循环 (AUC~418%).
  • 这种修改使肝脏积累量减少了高达47%.

结论:

  • 了解NBRP相互作用对于开发有效的纳米药物至关重要.
  • 表面化学和生物调制是改善纳米药物输送的关键策略.
  • 优化NBRP缓解导致更安全,更有效的纳米药物.