在移植治疗的治疗性非中低血症的风险评估
Chimezie Godswill Okwuonu1,2, Monarch Shah1, Iram Rafique1
1Division of Nephrology, University of Virginia Health, Charlottesville, Virginia, USA.
概括
低血是移植患者治疗性非 (TA) 期间的常见并发症,特别是在第一次治疗时. 肌水平升高和女性性别是这种不良事件的关键风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植手术 移植手术
- 关键护理医学 关键护理医学
背景情况:
- 在美国,治疗性阿菲雷斯 (TA) 越来越多地用于移植指示.
- 低血是TA期间经常出现的不良事件,但其患病率和危险因素尚未得到充分研究.
- 了解这些因素对于移植患者的安全至关重要.
研究的目的:
- 在接受脏移植的接受者中研究TA期间低血症的发生率和危险因素.
- 为了确定与低血症相关的患者和程序特征.
- 为了告知临床实践和改善患者的结果.
主要方法:
- 对接受TA治疗的成年患者进行移植指示的回顾性队列审查 (2017-2022年).
- 收集的数据包括人口统计数据,非症指示,手术细节以及血清/肌素水平.
- 统计分析,包括二进制物流回归,用于识别风险因素.
主要成果:
- 对131名患者和860个TA疗程的分析显示,在7%的疗程中出现了低血症.
- 大多数低血症事件 (88%) 发生在第一个TA课程期间.
- 风险因素包括女性性别 (OR 2.34),肌素水平升高 (OR 7.42) 和新鲜冷血的使用 (OR 5.01). 肌素的升高是一个独立的预测因子 (aOR 3.31).
结论:
- 低血症是接受TA的移植患者普遍出现的并发症.
- 警低血症,特别是在第一次治疗和肌素水平升高的患者中,是必不可少的.
- 量身定制的程序管理可以帮助减轻不利后果.
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