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Updated: Jun 24, 2025

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与HPK1失调相关的NK细胞功能障碍和缺陷扩张促进了转移性黑色素瘤的进展

Woo Seon Choi1, Hyung-Joon Kwon1, Eunbi Yi1

  • 1Department of Microbiology, Stem Cell Immunomodulation Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|June 3, 2024
PubMed
概括

肝瘤偏好蛋白激酶1 (HPK1) 的过度表达会损害自然杀手 (NK) 细胞的功能,促进癌症转移. 抑制HPK1可以增强NK细胞的活性,并在临床前模型中改善免疫治疗反应.

关键词:
功能障碍 功能障碍是指一种功能障碍.在HPK1中,HPK1是肺部转移 肺部转移 肺部转移黑色素瘤是一种黑色素瘤.自然杀手细胞是什么?

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