评估出生体重和儿童肥胖与骨关节炎的因果关系:孟德尔的随机化研究
Zengfeng Xin1,2,3,4, Lingxiao Xu1,2,3,4, Lingling Sun1,2,3,4
1Department of Orthopaedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
概括
儿童肥胖,而不是出生体重,与承重关节的骨关节炎 (OA) 有因果关系. 这表明肥胖症.
科学领域:
- 遗传学和流行病学
- 肌肉骨健康 肌肉骨健康
- 公共卫生 公共卫生
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 肥胖是已知的关节炎风险因素,但病因途径,特别是从早期开始的原因,仍然不清楚.
- 了解成人疾病的胎儿起源对于预防策略至关重要.
研究的目的:
- 使用孟德尔随机化研究出生体重,儿童肥胖和成人骨关节炎 (OA) 之间的因果关系.
- 为了确定出生体重或儿童肥胖是否独立地导致患有OA的风险.
- 探索潜在的调解因素,如成人体重指数,在儿童肥胖和OA之间的关联.
主要方法:
- 利用门德尔的随机化 (MR) 来评估早期生活因素和成人OA之间的因果关系.
- 从事全基因组关联研究 (GWAS) 的出生体重 (n=298,142) 和儿童肥胖 (n=24,160) 数据来自早期生长遗传学联盟.
- 分析了骨关节炎及其亚型 (膝盖,部,脊柱,手,指,手指) 的综合统计数据,来自骨关节炎遗传学联盟 (n=826,690).
- 执行多变量MR (MVMR) 来检查独立效应和潜在的介导途径.
主要成果:
- 基因预测的出生体重与整体或特定的OA类型没有显著的关联.
- 儿童肥胖症在统计学上显著,尽管边际,但对总体,膝盖,部和脊柱OA产生因果关系.
- 儿童肥胖和手,指或手指OA之间没有发现显著的关联.
- MVMR分析表明,从儿童肥胖到OA的潜在因果途径是由成年人体质指数调解的.
结论:
- 出生体重似乎对成人骨关节炎的发展没有因果关系.
- 儿童肥胖与骨关节炎有因果关系,特别是在承重关节 (膝盖,部,脊柱).
- 这些发现支持肥胖和OA之间的一般关联,儿童肥胖起着重要的因果作用,可能通过成人BMI.
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