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在男性阻塞性睡眠呼吸暂停中,小脑网络的异常动态功能连接和拓性质异常

Lifeng Li^1,2, Ting Long¹, Yuting Liu³

¹Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.

CNS neuroscience & therapeutics

|June 3, 2024

概括

阻塞性睡眠呼吸暂停 (OSA) 破坏大脑网络连接,特别是在小脑. 这些动态功能连接性变化与男性OSA患者的认知,情感和睡眠功能受损相关.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
系统生物学系统生物学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是一种普遍影响睡眠质量和全身健康的疾病.
小脑功能障碍已与OSA有关,但其动态功能连接 (dFC) 仍未得到充分研究.
了解OSA中大脑网络动态对于识别疾病机制和潜在的治疗点至关重要.

研究的目的:

调查大脑小脑全脑网络内的动态功能连接 (dFC) 在患有阻塞性睡眠呼吸暂停 (OSA) 的男性患者中.
在OSA中分析小脑网络的动态拓性质.
探索改变的大脑网络动态和OSA临床评估之间的关系.

主要方法:

使用滑窗方法检查60名男性OSA患者和60名男性健康对照的dFC波动和连接强度.
应用图形理论指标来评估小脑网络的动态拓特性.
采用隐藏的马尔科夫建模来验证dFC稳定性,并评估与临床数据的相关性.

主要成果:

确定了两个不同的动态网络状态,OSA患者在状态2中显示变化的频率,占用率和停留时间.
在网络中观察到大脑小脑dFC的显著变化,包括默认模式,前端对象和体运动网络,特别是涉及右大脑小脑CrusI/II.
揭示了异常的全球小脑拓和动态网络特性与情绪,认知和睡眠的临床指标之间的相关性.

结论:

男性OSA患者表现出异常的dFC,这表明大脑网络集成和隔离以及全球拓变化的不平衡.
在OSA中,默认模式网络与其他认知网络之间的交互中断可能会损害认知,情绪和睡眠功能的调节.

关键词:

小脑小脑是什么意思动态功能连接的功能连接.图形理论分析分析图形理论分析隐藏的马尔科夫模型阻塞性睡眠呼吸暂停 (SOP) 的情况.

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