功能障碍在儿科NAFLD/MASLD中很普遍,并且与疾病的严重程度有关
Marialena Mouzaki1, Katherine P Yates2, Ana Catalina Arce-Clachar1
1Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Journal of pediatric gastroenterology and nutrition
|June 3, 2024
概括
患有与代谢功能障碍相关的脂肪性肝病 (MASLD) 的儿童中,功能障碍和过是常见的. 近五分之一的儿童在两年内表现出功能恶化,这凸显了进一步研究的必要性.
科学领域:
- 儿科脏病学 儿科脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 患有非酒精性脂肪性肝病 (NAFLD/代谢功能障碍相关的脂肪性肝病 (MASLD)) 的成年人中,功能障碍很常见,并且与死亡率有关.
- 对于患有NAFLD/MASLD的儿童的功能,儿科数据有限.
研究的目的:
- 确定患有NAFLD/MASLD的儿童中过和慢性病 (CKD) 的患病率.
- 调查儿科NAFLD/MASLD患者功能障碍和肝病严重程度之间的关联.
主要方法:
- 从前性多中心儿科研究 (NASH-CRN) 中分析了1164名儿童的数据.
- 通过计算的淋巴膜过率 (cGFR) 评估功能;高过率定义为cGFR>135mL/min/1.73m2,CKD阶段≥2作为cGFR<90mL/min/1.73m2.
- 多项逻辑回归用于识别CKD和肝病严重程度之间的关联.
主要成果:
- 12%的儿童患有2-5阶段的CKD,27%患有过.
- 过独立地与显著的肝纤维化有关 (OR:1.45).
- 19%的儿童在2年内经历了功能障碍的恶化,独立于其他危险因素.
结论:
- 患儿NAFLD/MASLD时,功能障碍和过是很常见的.
- 过与此种人群中显著的肝纤维化有关.
- 显著少数儿童出现功能障碍的进展,因此需要通过额外的生物标志物进行进一步调查.
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