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埃科病毒11的遗传变异和进化特征:在中国发现的与新生儿死亡相关的基因型D5内的新变异
Liu Ying1,2, Sun Qiang1,2, Xiao Jinbo1,2
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Emerging microbes & infections
|June 3, 2024
概括
埃科病毒11 (E11),特别是基因型D5,显示广泛的循环和遗传变异. 这项研究绘制了其全球动态,并确定了关键突变,有助于理解严重的新生儿感染和开发控制策略.
科学领域:
- 病毒学 病毒学
- 分子进化分子进化
- 公共卫生 公共卫生
背景情况:
- 埃科病毒11 (E11) 与严重的新生儿感染有关.
- 最近爆发的新型E11基因型D5变种在中国,法国和意大利 (2018-2023) 造成了严重的新生儿病例和死亡.
- 关于E11循环和遗传变异的有限数据阻碍了预防和控制工作.
研究的目的:
- 调查11号埃科病毒的全球传播动态.
- 分析埃科病毒11基因型D5.5的遗传变异和分子进化.
- 为了解E11变体的致病性提供基础数据.
主要方法:
- 从中国国家急性性 (AFP) 和手足口病 (HFMD) 监测系统 (2000-2022) 收集了E11菌株.
- 利用了来自GenBank数据库的遗传序列.
- 进行了家族遗传学分析,以确定基因型D5集群和分子进化模式,包括突变部位和重组分析.
主要成果:
- 埃科病毒11基因型D5是全球占主导地位的基因型.
- 遗传学分析揭示了D5基因型的三个不同的地理集群:D5-CHN1 (2014-2019),D5-CHN2 (2016-2022) 和D5-EUR (2022-2023).
- 在VP1区域中确定了变异特异性氨基酸突变 (例如,在144位) 和积极选择压力位 (132,262). 检测到集群特定的重组模式,涉及CVB5,E6和CVB4.
结论:
- 这项研究提供了全球 Echovirus 11 循环模式的初步概述.
- 基因型D5表现出显著的地理聚类和分子进化.
- 鉴定的突变和重组事件为E11的致病性提供了洞察力,并为未来的研究和公共卫生干预提供了关键数据.
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