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一个散射薄膜自由电子束,以增加总皮肤电子疗法 (TSET) 的剂量率

George X Ding¹, Zhe Jay Chen², Kenneth Homann¹

¹Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Medical physics

|June 3, 2024

概括

采用6 MeV无分散薄膜 (SFF) 电子束的双场技术可以实现与标准方法相似的全皮电子疗法 (TSET) 剂量覆盖. 这种方法显著缩短了治疗时间,使TSET更容易被削弱的患者使用.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
放射治疗技术放射治疗技术

背景情况:

整体皮肤电子疗法 (TSET) 使用长距离 (300-700厘米) 的电子束进行均的皮肤覆盖.
目前的高剂量率全皮电子 (HDTSe) 模式具有有限的剂量率,导致治疗时间延长.
无分散薄膜 (SFF) 6 MeV电子束需要非常长的距离 (700厘米) 统一性,限制其临床使用.

研究的目的:

为TSET探索使用6 MeV-SFF光束的双场技术.
通过优化双场配置来缩短治疗距离.
为了克服治疗室大小对TSET交付所带来的限制.

主要方法:

利用EGSnrc系统进行碰撞光束生成和模拟.
针对6 MeV-SFF双场的优化廊角度,以匹配标准的6 MeV-HDTSe双场剂量分布.
使用基于治疗几何形状的剂量-体积-基因图进行患者皮肤剂量比较.

主要成果:

在6 MeV-SFF和6 MeV-HDTSe光束之间通过在400厘米和500厘米时调整8°和7°的门架角来实现可比剂量覆盖.
6 MeV-SFF光束在5-10毫米的深度提供了74%的处方剂量,而6 MeV-HDTSe则为74%.
6 MeV-SFF光束在10-15毫米的深度提供了49%的处方剂量,而6 MeV-HDTSe则为50%.

结论:

6 MeV-SFF电子束是可行的TSET与类似的皮肤剂量覆盖在源至表面距离 (SSD) ≥400厘米使用双场技术.
6 MeV-SFF光束的剂量速率大约是6 MeV-HDTSe光束的四倍,在400-500厘米的SSD.
这种技术显著减少了光束启动时间,提高了无法长时间站立的患者的TSET可访问性.

关键词:

蒙特卡洛模拟的蒙特卡洛模拟双场技术是双场技术的一种.散射薄膜可以发射自由电子束.整体皮肤电子疗法

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