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通过在大型护理中心的表面擦拭样本对环境抗生素污染的评估

Paul Sessink¹, Birgit Tans², David Devolder²

¹Exposure Control Sweden AB, Bohus-Björkö, Sweden.

The Journal of antimicrobial chemotherapy

|June 3, 2024

概括

在医院表面发现了抗生素污染,这表明医疗保健工作者可能受到暴露. 目前的清洁方法在减少广泛存在的抗生素残留物方面是无效的,这凸显了需要改进的处理策略的需要.

科学领域:

环境监测环境监测环境监测
制药污染制药污染制药污染
职业健康职业健康职业健康职业健康

背景情况:

医疗保健工作者 (HCW) 面临抗生素暴露的风险.
环境中的抗生素污染是潜在的HCW暴露的指标.
医院表面污染是药物安全的关键问题.

研究的目的:

评估医院病房中反复出现的抗生素表面污染情况.
评估对抗生素残留的清洁程序的有效性.
确定医疗保健机构中抗生素污染的来源和水平.

主要方法:

表面擦拭样本分析了八种常见的抗生素 (阿莫西西林,烯,塞福他西姆,塞夫特里亚,克洛沙西林,梅罗,皮佩拉西林,万科米辛).
采样在六个病房进行了为期8个月的采样,包括四个试验.
液体色谱与双重质谱 (LC-MS/MS) 用于定量药物分析.

主要成果:

所有八种抗生素都在准备桌子和地板上被始终检测到.
阿莫西西林的最高污染水平为1291 ng/cm2.
修改后的清洁程序并没有显著降低抗生素污染水平.

结论:

广泛的抗生素表面污染与泄漏和不有效的清洁有关.
开发安全的抗生素处理策略至关重要.
减少环境污染至关重要,以尽量减少HCW暴露于敏感药物.

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