减少危害的芬太尼测试条:一个范围审查
Eric Kutscher1, Marco Barber Grossi, Fred LaPolla
1From the NYU Grossman School of Medicine, New York, NY (EK, MBG, FLP, JDL); and Icahn School of Medicine at Mount Sinai, New York, NY (EK).
Journal of addiction medicine
|June 3, 2024
概括
芬太尼试验条 (FTS) 在检测非法药物中的芬太尼中显示出高精度. 然而,需要更多的研究来确认它们在预防过量服用和促进行为改变方面的有效性.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 药品安全 药品安全
背景情况:
- 芬太尼等高强度合成阿片类药物正在越来越多地污染北美非法药物供应.
- 芬太尼试验条 (FTS) 被用作预防过量服用的降低危害策略.
- 现有的证据支持FTS减少危害需要全面总结.
研究的目的:
- 系统地审查有关使用芬太尼试验条 (FTS) 作为减少危害的工具的现有证据.
- 评估FTS在预防过量服用和相关行为变化的有效性.
主要方法:
- 在2023年3月,在PubMed,Ovid Embase和Web of Science进行了全面的文献搜索.
- 一个两阶段的审查过程涉及标题/摘要选,随后由两个独立研究人员进行全文审查.
- 从包含的研究中提取数据,使用标准化模板.
主要成果:
- 九十一篇文章,主要来自北美,在2016年之后出版,被纳入了审查.
- 没有确定随机对照试验;证据主要集中在FTS的敏感性,特异性,可接受性和可行性.
- 有限的研究存在于FTS在促进行为改变,护理参与或过量预防方面的有效性.
结论:
- 芬太尼试验条 (FTSs) 显示出高灵敏度和特异性,用于点的护理药物测试.
- 进一步的研究至关重要,以确定FTS使用和过量预防之间的直接联系,特别是在不同的吸毒人口中.
- 需要增加投资,以调查FTS和其他护理点免疫测试在处理新型污染物 (如西拉和二) 和整体过量预防工作中的作用.
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