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谷氨基超母细胞核神经元对威胁性压力因素做出反应,并促进积极应对
Abraham Escobedo1, Salli-Ann Holloway1, Megan Votoupal2
1Department of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
eLife
|June 3, 2024
概括
研究人员在小鼠中发现了一个新的大脑电路,该电路在压力期间驱动积极的应对行为. 激活这些特定的神经元促进了对威胁的弹性和灵活反应,为焦虑症提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 精神病学研究 精神病学研究
背景情况:
- 威胁响应电路对于正常行为和精神疾病至关重要.
- 不适应的电路变化导致压力,情绪和焦虑障碍.
- 积极应对与应对压力诱导疾病的弹性有关,但其神经基础尚不清楚.
研究的目的:
- 为了研究主动应对行为背后的神经电路.
- 识别和描述参与威胁响应和应对的超母细胞核 (SuM) 中的一种新型神经元群.
主要方法:
- 使用小鼠模型来识别向前视区域 (SuMVGLUT2+::POA) 投射的谷氨酸性SuM神经元.
- 采用光遗传技术选择性地激活SuMVGLUT2+::POA和GABAergic SuM (SuMVGAT+) 神经元.
- 评估对压力因素的行为反应,包括厌恶,焦虑和积极的应对策略.
主要成果:
- SuMVGLUT2+:POA神经元被压力因素招募并与积极应对相关.
- SuMVGLUT2+的光激活:POA神经元诱导厌恶和积极应对行为,甚至在压力下将被动转换为积极应对.
- 激活SuMVGAT+神经元并没有影响厌恶或积极应对,但在停止刺激后可移动性增加.
结论:
- 建立了SuMVGLUT2+::POA神经元作为应激反应电路中的关键节点.
- 这些神经元连接到多个参与压力调节的大脑区域.
- SuMVGLUT2+::POA神经元驱动灵活的积极应对行为,表明焦虑和与压力相关的疾病的潜在治疗标.
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