根据风险组和性别差异,在使用他类药物的患者中遵守当前的失脂症指南:艾扎诺伊研究
Taner Şen1, Lale Dinç Asarcıklı2, Saadet Güven3
1Department of Cardiology, Faculty of Medicine, Kütahya Health Sciences University, Kütahya, Türkiye.
Anatolian journal of cardiology
|June 3, 2024
概括
对失脂症指南的遵守率很低,只有26.2%的他类药物治疗患者达到目标的LDL-C水平. 医生的惯性和需要组合治疗的需要是实现脂质目标的关键因素.
科学领域:
- 心脏病学 心脏病学
- 脂质学 脂质学是指脂质学.
- 临床实践指南 临床实践指南
背景情况:
- 评估遵守欧洲心脏病学会 (ESC) 脱脂症指南的情况.
- 评估不同心血管风险组的目标脂质值的实现.
- 确定在接受他类药物治疗的患者中未能达到低密度脂蛋白胆固醇 (LDL-C) 目标的原因.
研究的目的:
- 评估遵守当前欧洲心脏病学会脂质失调指南的情况.
- 根据他们的风险分层,确定达到目标LDL-C水平的患者比例.
- 确定在接受他类药物治疗的心脏病门诊患者中LDL-C控制低于最佳的主要原因.
主要方法:
- 在AIZANOI研究中,采用了多中心,横截面的观测设计.
- 2021年8月1日至2021年11月1日期间,从9个心脏病中心收集了数据.
- 包括1225名接受他类药物治疗至少3个月的患者.
主要成果:
- 只有26.2%的患者达到目标的LDL-C水平.
- 尽管在58.4%的非常高风险患者和44.4%的高风险患者中使用高强度他类药物,但指南建议的LDL-C水平仅分别达到24.5%和34.9%.
- 医生偏好或医生惯性是不使用目标剂量他类药物的最常见原因 (40.3%).
结论:
- 在接受他类药物治疗的心脏病门诊患者中,很少有 (26.2%) 达到指南推的LDL-C目标.
- 医生惯性显著有助于低于最佳的脂质管理.
- 大多数患者可能需要联合治疗才能达到LDL-C目标.
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