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Updated: Jun 24, 2025

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
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Published on: October 3, 2018

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贝耶-维利格单氧化酶催化细菌类核结构成熟的产品选择性

Manuel Einsiedler1,2, Katharina Lamm2, Jonas F Ohlrogge1,2

  • 1Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Department of Natural Product Biotechnology, Helmholtz Centre for Infection Research (HZI) and Department of Pharmacy at Saarland University, Campus E8.1, 66123 Saarbrücken, Germany.

Journal of the American Chemical Society
|June 3, 2024
PubMed
概括

像BraC和PxaB这样的Baeyer-Villiger单氧酶 (BVMOs) 从相同的中间体中产生不同的自然产物. 这项研究显示,BraC控制了布拉本胺的形成,而PxaB的选择性取决于基质结构.

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