在接受10kHz脊髓刺激治疗的患者中定义短期和长期编程要求
David A Provenzano1, Jozef E Leech1, Marina Bendersky2
1Pain Diagnostics and Interventional Care, Sewickley, PA, USA.
概括
高频脊髓刺激 (10kHz SCS) 有效地治疗慢性疼痛,大多数患者获得了显著的疼痛缓解和功能改善. 植入后需要最小的编程才能保持这些积极的结果.
科学领域:
- 神经学 神经学
- 疼痛管理 疼痛管理
- 医疗器械 医疗器械
背景情况:
- 高频脊髓刺激 (10kHz SCS) 已被公认为用于治疗耐火性腰部和部疼痛.
- 关于10kHz SCS.最佳缓解疼痛所需的编程参数的数据有限.
研究的目的:
- 分析接受10kHz SCS治疗慢性疼痛的患者的编程参数和结果.
- 为有效的疼痛管理提供有关编程要求的见解.
主要方法:
- 从部和腰部疼痛患者的临床和设备数据的回顾性分析.
- 评估最佳的双重情绪,刺激参数,缓解疼痛,阿片类药物使用,睡眠和功能.
主要成果:
- 64%的植入患者获得了50%以上的疼痛缓解,65%减少了阿片类药物使用,65%改善了睡眠,71%改善了功能.
- 在试验和永久植入物之间观察到很高的一致性.
- 为了保持结果,需要最小的设备重编程 (每季度每患者≤1).
结论:
- 10kHz SCS是慢性疼痛的有效疗法,显示出高响应率和快速缓解疼痛.
- 在永久植入后,通过有限的设备编程来维持治疗疗效.
相关概念视频
01:35Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...