在非慢性病患者群体中,高尿血和慢性冠状动脉全封闭之间的关联:一个横截面研究
Jianping Wang1, Xiaoli Chen2, Zhongwei He1
1Departments of Cardiology.
Coronary artery disease
|June 3, 2024
概括
超尿血 (HU) 与没有慢性病的个体患慢性冠状动脉全封闭 (CTO) 的风险较高有关. 这种关联在年轻,非肥胖和脂质障碍患者中尤为强烈.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 慢性冠状动脉全封闭 (CTO) 带来了重大的健康挑战和经济负担.
- 高尿路血 (HU) 经常在动脉样硬化患者中观察到.
- 关于HU和CTO风险之间的关联以及传统心血管风险因素的影响的研究有限.
研究的目的:
- 为了研究高尿血和发展慢性冠状动脉完全封闭的风险之间的关系.
- 在HU和CTO的背景下探索传统心血管风险因素的作用.
主要方法:
- 研究了一组1245名没有慢性病的中国西南地区冠状动脉血管造影的个人.
- CTO被定义为超过3个月的冠状动脉封闭;HU被定义为特定的血清尿酸水平.
- 用物流回归模型和子组分析来评估HU-CTO协会.
主要成果:
- 经过调整后的分析显示,HU与CTO风险增加1.47倍有关 (OR,1.47;95% CI,1.06-2.58;P=0.026).
- 血清尿酸水平独立预测了CTO风险 (OR,1.002;95%CI,1.001-1.004;P=0.047) 的情况.
- 较高的CTO风险观察到65岁以下的个人,非肥胖的个人,以及患有脂质失调症的人,但性别,吸烟,高血压或糖尿病并没有显著影响.
结论:
- 在中国西南部的非CKD个体中,高尿路血与CTO的风险增加有关.
- 在年轻人 (<65岁),非肥胖者和失脂症患者中,增加的风险尤其显著.
- 这些发现强调了HU作为特定患者亚组中CTO的潜在风险因素.
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