认知和运动能力下降的共享血代谢概况预测了未来的痴呆症
Qu Tian1, Shanshan Yao2, Megan M Marron2
1Longitudinal Studies Section, National Institute on Aging, 251 Bayview Blvd M04B332, Baltimore, MD, 21224, USA. qu.tian@nih.gov.
GeroScience
|June 3, 2024
概括
认知和运动能力的下降显著增加了痴呆症的风险. 特定的血液代谢物,包括氨基酸和脂质,与衰退有关,并预测痴呆症,这表明共享的潜在途径,如炎症.
科学领域:
- 老年学和神经科学 在
- 代谢学和生物标志物发现发现
背景情况:
- 同时的认知和身体功能下降会增加痴呆症的风险,远远超过仅仅认知能力下降.
- 识别认知和移动能力下降的共同生物学途径和早期预测因素对于预防痴呆症至关重要.
研究的目的:
- 调查血代谢物与认知和移动性同时下降之间的关联.
- 通过将认知障碍与运动障碍联系起来,确定作为痴呆风险早期预测剂的特定代谢物.
主要方法:
- 分析了2450名在基线没有痴呆症的老年人血代谢物数据 (健康,衰老和身体组成研究).
- 10年来认知功能 (3MS) 和步行速度的纵向评估,痴呆症诊断追踪到2014年.
- 多变量回归模型检查了代谢物与认知和步行速度变化的关联;考克斯回归分析了痴呆症风险.
主要成果:
- 26种血代谢物与认知能力和步行速度的下降显著相关.
- 其中18种共享代谢物,包括氨基酸,甘油脂和脂,与痴呆风险增加有显著的关联.
- 在调整心血管疾病和阿波利波蛋白E ɛ4载体状态后,关联仍然很强.
结论:
- 独特和共享的代谢特征是衰老过程中认知和运动能力下降的基础.
- 共享的代谢物表明炎症,线粒体功能障碍和尿素循环缺陷在预测痴呆症中的关键作用.
- 这些发现突出了潜在的早期生物标志物和痴呆症的治疗点,通过解决相互连接的生理途径.
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