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仿生和伤口微环境调节PEGylated甘油聚酸水凝用于动脉大规模出血和伤口前期愈合
Lin Teng1, Yingying Song1, Yinghan Hu2
1School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Biomacromolecules
|June 3, 2024
概括
新的注射型甘油聚酸水凝为动脉出血提供优质的血液静止,并通过调节炎症环境促进伤口愈合,优于传统治疗方法.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 血液静止 血液静止 血液静止
背景情况:
- 现有的水凝血静止剂和敷料往往无法承受动脉出血压力,缺乏有效的伤口愈合的生物活性.
- 动脉出血和复杂的伤口需要先进的材料,具有强大的静血和治疗性质.
研究的目的:
- 设计和评估可注射的生物模拟PEGylated甘油聚水凝,用于控制动脉出血和增强伤口愈合.
- 调查水凝调节伤口微环境的能力,并促进M2巨细胞两极分化.
主要方法:
- 合成可注射的PEGylated甘油聚酸水凝与曼诺斯修饰.
- 在实验室中对水凝特性进行表征 (粘附性,破裂压力,多孔性,生物相容性).
- 在大鼠肝脏和子大腿动脉出血模型的体内评估,以及大鼠的全厚伤口愈合模型.
主要成果:
- 水凝凝迅速 (∼10秒),表现出高组织粘附性 (∼20kPa),破裂压力 (∼150mmHg) 和生物相容性 (∼1%的血液溶解).
- 与对照人群相比,实现了快速的动脉血静止 (<20秒),血液损失显著减少 (5-13%).
- 促进了M2巨细胞的两极分化,减少了瘤亡因子-α,并加速了具有显著原沉积 (90%) 的完整伤口愈合.
结论:
- 生物仿真甘油聚酸水凝为控制动脉出血和促进伤口愈合提供了一个多功能平台.
- 这些水凝有效地抵抗血管压力,调节炎症微环境,加速组织再生.
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