双A和酸盐与越南儿童早期青春期的关系
Quynh Thi Vu Huynh1,2, Ho Tran Ban3,4, Nguyen Lam Vuong5
1Department of Pediatrics, 249295 University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City, Vietnam.
概括
尿中的双甲 (BPA) 和双甲酸 (DBP) 在早期青春期 (PP) 的儿童中更为普遍. 这表明这些环境化学物质与儿童青春期早期发作之间存在潜在联系.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 儿科 儿科 儿科
背景情况:
- 过早的青春期 (PP) 是一种以青春期的早期发作为特征的疾病.
- 暴露于环境内分泌干扰化学物质,如双A (BPA) 和酸盐,已经被调查了与PP的潜在联系.
研究的目的:
- 研究尿液中双A (BPA),二甲基甲酸盐 (DEHP) 和二甲基甲酸盐 (DBP) 的含量与早期青春期 (PP) 的风险之间的关联.
- 探索特定化学物质暴露和儿童中PP的发生之间的相关性.
主要方法:
- 在越南胡志明市进行了一项病例控制研究.
- 该研究包括250名儿童:124名被诊断患有PP (病例) 和126名没有PP (对照).
- 用经过验证的分析方法测量了BPA,DEHP和DBP的尿度.
主要成果:
- 双甲 (BPA) 在11.3%的早期青春期病例中被检测到,但在没有一个对照群中 (p<0.001).
- 在任何样本中都没有检测到二甲基甲酸代谢物 (MEHP).
- 在8.1%的PP病例和2.4%的对照中发现了二甲甲酸代谢物 (MBP),这表明PP的几率增加了3.6倍 (95%CI:0.97-13.4,p=0.03).
结论:
- 与对照组相比,早熟青春期的儿童在尿液中呈阳性BPA和DBP水平的患病率明显高.
- 这些发现表明BPA和DBP暴露与早期青春期的发展之间存在潜在的关联.
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