[狼性炎中的NETosis]
T M Reshetnyak1,2, K S Nurbaeva1,2, I V Ptashnik3
1Nasonova Research Institute of Rheumatology.
Terapevticheskii arkhiv
|June 3, 2024
概括
在39%的系统性红斑狼 (SLE) 患者中发现了高水平的髓氧化酶-DNA (MPO-DNA) 复合物. 这种MPO-DNA复合体与狼性炎 (LN) 活动和SLE患者的损伤有关.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 系统性红斑狼 (SLE) 是一种具有潜在器官损伤的慢性自身免疫性疾病.
- 狼性炎 (LN) 是SLE的严重表现,影响功能.
- 髓氧化酶 (MPO) 是中性粒细胞激活过程中释放的酶,MPO-DNA复合体是NETosis的标记物.
研究的目的:
- 为了评估SLE患者的MPO-DNA复合物的水平.
- 评估MPO-DNA复合体水平与LN的存在和活性之间的关联.
主要方法:
- 使用ELISA测量了77名SLE患者和20名健康对照者的血清MPO-DNA复杂水平.
- SLE患者包括那些有和没有抗脂综合征 (APS) 的患者.
- 分析了与LN病史,活跃LN,尿液分析结果和SLEDAI-R相关的关联.
主要成果:
- 与对照组相比,SLE患者的MPO-DNA复合物水平明显高于对照组 (p=0.001).
- 升高的MPO-DNA复合体水平与LN (p=0.009) 和活性LN (p=0.034) 的病史有关.
- 在活跃的LN中,MPO-DNA复合体水平与蛋白尿,血尿,形,白细胞尿和SLEDAI-R相关.
结论:
- 39%的SLE患者的MPO-DNA复合体水平升高.
- 升高的MPO-DNA复合体与较高的LN的流行率和活性有关.
- MPO-DNA复合物可能作为SLE中损伤活性的潜在生物标志物.
关键词:
这是一个MPO-DNA复合体.网症 (NETosis) 是一种疾病.网络 网络 网络 网络狼性炎是一种神经炎症.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.更多相关视频
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