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轮动力血的多目标优化:空腔肺辅助装置的使用案例

Andreas Escher¹, Spasoje Miric², Bente Thamsen¹

¹From the Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

|June 3, 2024

概括

这项研究通过同时考虑尺寸,血液兼容性和运动效率来优化旋转动力血 (RBPs) 进行腔肺支. 多目标优化实现了72.4%的血红相容性改善,体积减少1.5%,证明了可行的权衡.

科学领域:

生物医学工程生物医学工程
医疗器械医疗器械
流体动力学流体动力学

背景情况:

优化轮动力血 (RBPs) 需要平衡相互矛盾的目标:大小,血液相容性和运动效率.
独立优化限制了RBP设计的多目标方法的潜力.
腔肺支需要具有集成性能特征的高级RBPs.

研究的目的:

为了执行一个多目标优化旋转动力血 (RBP) 洞肺支.
为了同时考虑的大小,血液相容性和运动效率.
为了确定平衡这些关键性能指标的帕雷托最佳设计.

主要方法:

使用计算流体动力学 (CFD) 和计算电磁学 (CEM) 进行特征化液压和电磁设计空间.
定义的设计变量包括二次流量间隙宽度,螺旋直径和定子高度.
在81个设计中使用帕雷托分析来确定21个帕雷托最佳解决方案.

主要成果:

确定了帕雷托前线,证明了关键的RBP绩效目标之间的权衡.
在体积减少1.5%的情况下,血液相容性得到了72.4%的改善.
在保持可接受的温度上升 (<0.4 K) 的同时,观察到电机损耗小幅增加 (0.2 W).

结论:

多目标优化可以显著提高血红相容性和减少RBP的体积.
在改善血红相容性/减小体型和运动效率之间存在可行的权衡.
已识别的帕雷托前线为设计用于洞肺支的先进RBP提供了宝贵的见解.

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