维生素D受体基因多态,生物可用25-氧维生素D,以及肝细胞癌存活率
Jing Shu1, Mingjie Zhang1, Xiaocong Dong1
1Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Journal of the National Cancer Institute
|June 3, 2024
概括
维生素D受体基因变异影响肝细胞癌 (HCC) 的存活率. 优化维生素D水平可能会改善具有特定遗传特征的患者的治疗结果.
科学领域:
- 遗传学和瘤学研究
- 营养生物化学 营养生物化学
- 癌症预后 癌症预后
背景情况:
- 对维生素D受体 (VDR) 基因多态性和肝细胞癌 (HCC) 预后中的维生素D状态的有限理解.
- 研究VDR多态和维生素D水平之间的相互作用对于预测HCC结果至关重要.
研究的目的:
- 评估特定的VDR多态 (TaqI,BsmI,Cdx-2,ApaI) 与HCC存活率的相关性.
- 为了确定VDR多态性是否改变血清生物可用25-氧维生素D (25OHD) 和HCC预后之间的关系.
主要方法:
- 在967名新诊断的HCC患者中分析了TaqI,BsmI,Cdx-2和ApaI多态性.
- 利用考克斯的比例危险模型来评估与肝癌特定存活率 (LCSS) 和整体存活率 (OS) 的关联.
- 研究了VDR多态性和血清生物可用25OHD度与生存结果之间的相互作用.
主要成果:
- TaqI G代基因和BsmI T代基因与更糟糕的LCSS有关.
- 保护性等位基因携带的增加与高级LCSS相关.
- 在具有特定VDR基因型 (TaqI AA,BsmI CC) 和具有6-8个保护性等位基因的患者中,生物可用25OHD和LCSS之间的反向关联是显著的.
结论:
- 野生类型的TaqI和BSMI基因型,或携带更多的保护性等位基因,与改善的HCC存活率有关.
- 具有这些遗传特征的患者可以从优化其生物可用性25OHD状态中获益,以获得更好的预后.
相关概念视频
01:21Cancer Survival Analysis
343
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
343
01:23Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K