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Updated: Jun 24, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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基于结构的鉴定G蛋白偏差的可nabinoid受体CB1的全调节器

Siyuan Shen1,2, Chao Wu1, Guifeng Lin1

  • 1Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Proceedings of the National Academy of Sciences of the United States of America
|June 3, 2024
PubMed
概括

新的大麻衍生化合物称为agonist-allosteric调节剂 (ago-BAMs) 选择性地激活特定的CB1受体通路. 这提供了一个潜在的非阿片类药物止痛策略,副作用较少,没有成风险.

关键词:
在GPCR中,GPCR是指GPCR.在过去的BAMs.大麻素受体CB1 CB1是什么?非阿片类止痛药是一种非阿片类止痛药.疼痛管理 疼痛管理

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