在早产前硫酸用于神经保护:更新的柯克兰系统性审查
Emily S Shepherd1, Shona Goldsmith, Lex W Doyle
1SAHMRI Women and Kids, South Australian Health and Medical Research Institute (SAHMRI), and Adelaide Medical School, University of Adelaide, Adelaide, the Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, and the Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Australia; INSERM Unit 1245, Team 4, Rouen School of Medicine, Normandy University, and the Department of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital, Rouen, France; Women & Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, Rhode Island; the Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; the Department of Gynaecology and Obstetrics, Hvidovre University Hospital, Hvidovre, Denmark; and the Liggins Institute, University of Auckland, Auckland, New Zealand.
给有早产风险的母亲服用硫酸可显著降低儿童脑的风险. 虽然它提供神经保护,但需要进一步研究长期影响和在不同人群中的适用性.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿神经病学 新生儿神经病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过早分娩对新生儿神经发育构成重大风险.
- 硫酸被研究为潜在的神经保护剂的胎儿暴露于早产.
- 之前的系统审查已经为目前对其有效性和安全性的理解提供了信息.
结论:
- 硫酸有效降低早产婴儿的脑和死亡或脑的综合结果.
- 治疗增加了母亲的不良反应,需要停止治疗 (中度确定性证据).
- 需要进一步研究长期结果,效果调整因子和对低收入和中等收入国家普遍性的研究.


