糖尿病黄斑的长期治疗模式:在IRIS®注册表中进行长达6年的随访
Blanche L Kuo1, David Tabano2, Vincent Garmo2
1Case Western Reserve University School of Medicine, Cleveland, Ohio; Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
Ophthalmology. Retina
|June 3, 2024
概括
在美国,针对糖尿病黄斑瘤 (DME) 的抗VEGF内疗法 (IVT) 显示注射次数较少,间隔时间比推更长,初始视力较差患者的视力有所改善.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理疗法 药理疗法 药理疗法
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 抗VEGF体内治疗 (IVT) 是对DME的标准治疗方法.
- 关于长期治疗模式和结果的真实数据至关重要.
研究的目的:
- 分析美国临床实践中针对DME的抗VEGFIVT模式.
- 评估长期视力敏度 (VA) 结果,长达6年.
- 确定与治疗结果相关的因素.
主要方法:
- 对IRIS®注册表 (190,345只眼睛) 的回顾分析.
- 包括之前没有接受过治疗的DME患者开始抗VEGFIVT (2015-2021年).
- 评估注射频率,VA变化和停止治疗.
主要成果:
- 平均每年注射量在6年内下降,间隔增加.
- 视力改善的眼睛与更糟糕的基线VA;视力下降的眼睛与良好的基线VA.
- 更糟糕的结果与西班牙裔种族,医疗补助保险和年龄较大有关.
结论:
- 针对DME的真实世界抗VEGFIVT涉及的注射量比临床试验或标签建议要少.
- 治疗模式和结果因基线视力和人口因素而异.
- 需要进一步的研究来优化日常护理中的DME管理.
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