菌根菌:用于治疗菌根菌感染的治疗方法
Sunil Kumar Raman1, D V Siva Reddy1, Vikas Jain2
1Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Drug discovery today
|June 3, 2024
概括
菌体在治疗结核病 (TB) 和非结核性菌根性肺病 (NTM-LD) 中表现有前途. 本综述涵盖了菌体治疗的发展,包括这些具有挑战性的感染的机制,调节途径和肺部传递.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 生物技术是生物技术.
背景情况:
- 结核病 (TB) 仍然是全球主要的健康问题.
- 非结核菌菌 (NTM) 肺病 (NTM-LD) 的发病率正在增加.
- 菌体为治疗细菌感染提供了一个潜在的替代方案.
研究的目的:
- 审查菌体及其产品用于治疗Mycobacterium结核病和NTM.
- 探索菌体机制以准细胞内细菌.
- 讨论药物开发和工业生产的菌体疗法.
主要方法:
- 在真菌菌菌感染中对菌体应用的文献综述.
- 对菌体机制的分析,包括免疫逃避.
- 检查药品开发和制造过程.
- 对菌体产品的肺部输送策略的审查.
主要成果:
- 菌体和它们的lysins显示出对M.结核病和NTM的有效性.
- 菌体可以潜在地访问和消除巨细胞寄居的菌体.
- 概述了开发和生产基于菌体的治疗方法.
- 讨论了工业生产和肺部输送方法.
结论:
- 菌菌治疗为对抗结核病和NTM-LD提供了一个可行的策略.
- 临床翻译需要进一步的研究和开发.
- 案例研究突出了mycobacteriophage治疗的潜力.
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