已知和未知:研究塑料添加剂的致癌潜力
Sophia Vincoff1, Beatrice Schleupner2, Jasmine Santos1
1Department of Medicine and the Duke Cancer Institute Center for Prostate and Urologic Cancer, Duke University Medical Center, Durham, North Carolina 27710, United States.
Environmental science & technology
|June 3, 2024
概括
许多塑料添加剂具有致癌性或缺乏安全数据,造成健康风险. 需要紧急评估和规定,以解决塑料添加剂暴露的潜在危险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 基因组学就是基因组学.
背景情况:
- 微塑料及其添加剂经常被摄入和吸入.
- 塑料暴露的健康后果,尤其是添加剂的健康后果,人们了解得很少.
- 添加剂可以从塑料中浸出,增加暴露风险.
研究的目的:
- 评估已知塑料添加剂的致癌性.
- 为了确定受塑料添加剂影响的生物途径.
- 为塑料添加剂安全性的监管策略提供信息.
主要方法:
- 编制了一个包含 2,712 种塑料添加剂的数据库.
- 进行了综合毒基因组分析,重点关注癌症途径.
- 使用化学数据库选添加剂并分析化学基因相互作用.
主要成果:
- 超过150种塑料添加剂被确定为已知的致癌物.
- 大约90%的添加剂缺乏致癌性数据.
- 致癌和非致癌添加剂影响了类似的途径,包括DNA损伤,免疫反应和癌症.
结论:
- 许多塑料添加剂具有已知的致癌性.
- 大多数添加剂的致癌潜力存在广泛的数据缺口.
- 迫切需要对塑料添加剂进行全面的致癌性评估和监管行动.
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