用贝瓦齐祖马布进行新辅助化疗,用于局部发达的癌
Theresa M Kuhn1, Sarfraz Ahmad2, Fernando O Recio2
1Gynecologic Oncology, AdventHealth Cancer Institute, Orlando, Florida, USA tmkuhn2@gmail.com.
概括
用金,帕克利塔克塞尔和贝瓦齐祖马布进行的新辅助化疗改善了局部晚期癌的结果,使得手术完全切除和良好的伤口愈合.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 局部晚期癌的标准治疗包括用进行辐射,通常会引起副作用并使手术复杂化.
- 对于持久性疾病的辐射后手术可能导致伤口愈合不良.
研究的目的:
- 为了评估新辅助化疗加贝瓦齐祖马布的临床结果,然后对局部发达的癌进行激进的切除术.
主要方法:
- 对接受新辅助化疗的13名II-IV期癌患者的回顾性分析 (卡博普拉丁/西斯普拉丁,帕克利塔克塞尔,贝瓦西祖马布).
- 评估病理反应,手术边缘,不良反应和生存结果.
主要成果:
- 九名患者 (69.2%) 获得了部分病理反应,四名患者 (30.8%) 获得了完全反应.
- 所有患者都取得了负的外科边缘;只有一个患上了表面沟血清瘤.
- 三名患者出现了复发 (两个局部,一个远程),有一人死亡;中位数随访时间为23个月.
结论:
- 新辅助剂/帕克利塔克塞尔/贝瓦西祖马布对局部晚期的癌有效,促进了完整的切除和良好的伤口愈合.
- 建议在多机构的II期试验中进一步验证.
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