患有海马硬化症的患者的记忆变化,接受了手术,以治疗 mesial temporal lobe 发作
E Leal-Conceição1, M Muxfeldt Bianchin2, W Vendramini Borelli3
1Epilepsy Surgery Program, Neurology, Neurosurgery and Neuropsychology Services, Hospital São Lucas, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Brain Institute of Rio Grande do Sul (BraIns), PUCRS, Porto Alegre, Brazil; Faculty of Medicine, UFRGS, Porto Alegre, Brazil.
Neurologia
|June 3, 2024
概括
由于海马硬化症 (HS) 导致的耐火性 mesial temporal lobe (MTLE) 的手术影响记忆力. 左侧HS和较老的发作发病年龄预测手术后的后期逻辑记忆 (LM) 更差.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 认知神经科学 认知神经科学
背景情况:
- 由于海马硬化症 (HS) 的耐火性 (MTLE) 通常需要手术干预.
- 手术后的认知功能,特别是记忆,是关键的结果衡量标准.
研究的目的:
- 分析患有MTLE/HS的患者间的科和外科变量与术后记忆表现之间的关系.
- 为了确定手术后记忆变化的预测因素.
主要方法:
- 对201名接受MTLE/HS手术的患者的逻辑记忆 (LM) 和视觉记忆 (VM) 评分的审查.
- 与对照组比较得分的标准化,并计算个人记忆变化可靠变化指数 (RCI).
- 多重线性回归分析以确定记忆结果的预测因素.
主要成果:
- 左侧HS和发作开始时的晚年预测晚期LM的情况会更糟.
- 右HS患者在LM和VM中显示出更高的可靠术后改善率.
- 在左HS组观察到较差的基线LM功能.
结论:
- 左侧MTLE/HS和发作发作时的晚年是晚期LM衰退的显著预测因素.
- 右侧切除可能与更好的记忆结果有关.
- 个人的记忆变化各不相同,突出了个性化结果评估的必要性.
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