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越紧越好:一个简单而免费的参数可以预测对心脏同步治疗的反应吗?

Giuseppe Coppola¹, Cristina Madaudo¹, Giosuè Mascioli²

¹Operative Unit of Cardiology - UTIC, University Hospital "Paolo Giaccone", University of Palermo, AOUP Paolo Giaccone, Via del Vespro 129, Palermo, Italy.

Pacing and clinical electrophysiology : PACE

|June 3, 2024

概括

心脏再同步治疗 (CRT) 后QRS指数 (QI) 缩小预测心脏功能改善和不良事件减少. 这一指标可以更好地预测CRT反应,无论患者的并发症如何.

科学领域:

心脏病学心脏病学
医疗器械医疗器械
心脏衰竭管理的管理

背景情况:

心脏再同步治疗 (CRT) 的有效性通常使用QRS持续时间 (QRSd) 来评估.
确定可靠的CRT反应预测因子对于优化患者的治疗结果和降低非反应率至关重要.

研究的目的:

评估QRS指数 (QI) 的相对变化与接受CRT的患者的临床结果之间的相关性.
确定智商是否是CRT植入后逆重塑和预后的预测指标.

主要方法:

一项多中心研究,涉及398名使用CRT设备的患者.
测量临床,心声和药理学变量,包括CRT前后的QRSd和QI.
在6个月和24个月后进行后续评估,以评估左心室重塑和临床事件.

主要成果:

在CRT后观察到左心室喷射分数 (LVEF) 和体积的显著改善.
智商与反向改造有显著的相关性 (调整后的r平方:0.43,p=0.001),预测LV反向改造的截止值为12.25%.
较低的QI与更好的结果有关,包括减少NYHA类恶化和降低心血管死亡率.

结论:

在CRT后QRS指数 (QI) 缩小与增强的心声逆向重塑和较少的不良事件有关.
智商作为一个有价值的预测CRT反应,独立于并发症.
该研究表明,QI可以改善CRT患者不良事件的预测.

关键词:

通过CRT的心脏再同步治疗治疗.在QRS指数中,QRS是指数.在QRS收窄.心脏衰竭是因为心脏衰竭.没有回应的非响应者.应对者应对者应对者应对者应对者

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