乳腺癌患者二次甲状腺癌的危险因素:与倾向相匹配的SEER分析
Yizhuo Diao1, Ruiqi Wang1, Jiaxue Cui1
1Department of Epidemiology and Health Statistics, Dalian Medical University, 9 Lvshun South Road, Dalian, 116044, Liaoning, China.
Scientific reports
|June 3, 2024
概括
乳腺癌幸存者面临患二次甲状腺癌的风险增加,这是由于共同的荷尔蒙敏感性. 这项研究确定了关键的风险因素,并开发了早期干预的预测模型.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 提高乳腺癌存活率导致二次原发性癌症发病率增加.
- 乳腺和甲状腺组织对激素敏感,这表明它们的发展存在潜在的联系.
- 了解乳腺癌患者二次甲状腺癌的风险因素对于改善患者的治疗结果至关重要.
研究的目的:
- 在乳腺癌患者中确定二次甲状腺癌的独立风险因素.
- 开发一个预测模型来估计二次甲状腺癌的风险.
- 通过预测二次甲状腺癌,提高乳腺癌患者的生存概率.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库 (2010-2019) 的数据.
- 员工倾向得分匹配,以平衡案例和对照组.
- 应用单变量和多变量COX比例回归分析以确定风险因素并构建一个名ogram预测模型.
主要成果:
- 确定了年龄,种族,放射治疗,原发性瘤位置,N期和M期作为二次甲状腺癌的独立风险因素.
- 开发了一种预测3年和5年生存概率的名图.
- 在训练组中达到0.713 (3年) 和0.707 (5年) 的AUC值,在验证组中达到0.681.
结论:
- 在乳腺癌患者中建立了二次甲状腺癌的预测模型.
- 该模型有助于识别有针对性的监测和干预的高风险个人.
- 强调在长期癌症幸存者护理中考虑内分泌相关因素的重要性.
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