相关实验视频

Updated: Jun 24, 2025

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

代谢表型和酒精消费对代谢功能障碍相关脂肪肝疾病的死亡风险的影响:基于人口的队列研究

Phunchai Charatcharoenwitthaya¹, Khemajira Karaketklang², Wichai Aekplakorn³

¹Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. phunchai@yahoo.com.

Scientific reports

|June 3, 2024

概括

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 患者患有糖尿病或瘦体表型面临更高的死亡风险. 酒精消费显著增加死亡风险,特别是在瘦肉MAFLD患者中.

科学领域:

肝病学肝病学是一种肝病学.
代谢疾病代谢疾病
公共卫生公共卫生

背景情况:

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 通常与代谢问题和酒精使用并存.
这些因素可能会影响患者的预后和临床结果.
了解这些相互作用是有效的MAFLD管理的关键.

研究的目的:

调查不同MAFLD表型对死亡风险的影响.
为了检查MAFLD患者的酒精消费和死亡率之间的关系.
探索代谢表型和酒精摄入量对死亡率的综合影响.

主要方法:

分析泰国国家健康检查调查中8043名MAFLD参与者的数据.
MAFLD表型的分类:糖尿病,超重/肥胖,以及瘦肉代谢.
考克斯的比例危险模型用于评估死亡风险,对共变量进行调整.

主要成果:

糖尿病 (aHR 1.59) 和瘦代谢 (aHR 1.28) 现型显示出明显更高的死亡风险比超重/肥胖现型.
一个J形曲线表明,随着每日饮酒量增加,全因死亡率增加.
过度饮酒增加了瘦肉MAFLD患者的死亡风险 (aHR 3.39).

结论:

MAFLD代谢表型和酒精消费相互作用,影响所有原因的死亡风险.
这两个因素对于评估MAFLD的预后和指导管理策略至关重要.
考虑到表型和酒精摄入量的个性化风险评估对于MAFLD患者至关重要.

关键词:

酒精消费酒精消费酒精消费马夫尔德 (MAFLD) 是一个代谢表现型的代谢表现型死亡率死亡率死亡率 2 型糖尿病 2 型糖尿病

更多相关视频

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

Published on: November 15, 2024

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

相关概念视频

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Metabolic States of the Body: Fasting and Starvation

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...