严重程度和年龄对神经发育结果的影响与支气管肺功能失调的可变定义
Jack Donlon1, Vishwanath Bhat1,2, Krystal Hunter1,3
1Cooper Medical School of Rowan University, Camden, NJ, USA.
Pediatric research
|June 3, 2024
概括
目前的支气管肺功能障碍症 (BPD) 定义可能无法有效预测早产婴儿的神经发育障碍 (NDI). 詹森2019标准和40周PMA的呼吸支持显示了NDI的类似预测能力.
科学领域:
- 新生儿医学 新生儿医学
- 儿科神经学 儿科神经学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿的慢性肺部疾病.
- BPD经常与神经发育障碍 (NDI) 相关.
- 准确预测NDI对于早期干预至关重要.
研究的目的:
- 为了比较NICHD 2001年和Jensen 2019年对NDI的BPD定义的预测能力.
- 为了评估40周月经后年龄 (PMA) 和NDI之间的呼吸支持之间的关联.
- 评估不同BPD标准在识别患有NDI风险的婴儿方面的比较有效性.
主要方法:
- 对妊娠年龄<32周,出生体重<1500克 (1/2010-12/2020) 的婴儿进行了回顾性研究.
- 神经发育障碍 (NDI) 评估在18-24个月的校正年龄.
- 多变量回归和ROC曲线分析用于比较BPD定义和40周PMA呼吸支持的预测值.
主要成果:
- 根据NICHD 2001 BPD定义,没有预测NDI.
- 患有2级或3级BPD的婴儿 (Jensen 2019) 的NDI几率明显更高 (4.75倍).
- 在40周PMA需要呼吸支的婴儿,NDI的几率明显更高 (4.95倍).
结论:
- 2001年NICHD和詹森2019年BPD定义预测NDI的能力没有显著差异.
- 40周的呼吸支PMA显示了与BPD定义相似的NDI的预测能力.
- 目前的BPD定义可能需要改进,以更好地预测早产婴儿的NDI.
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