内生乙醇生产在健康和疾病中的作用
Abraham S Meijnikman1, Max Nieuwdorp2,3,4, Bernd Schnabl5,6,7
1Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Nature reviews. Gastroenterology & hepatology
|June 3, 2024
概括
肠道微生物群通过微生物代谢物如乙醇影响宿主代谢. 过度的肠道乙醇生产可能导致肝脏疾病和代谢功能障碍,需要针对性的干预措施.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群通过循环的微生物代谢物显著影响宿主代谢.
- 肠道平衡的破坏会改变微生物代谢物,解释了血代谢学中的显著差异.
- 乙醇是一种常见的肠道微生物代谢物,但高水平与代谢功能障碍相关的脂肪性肝病和自动酒综合征等病理状况有关.
研究的目的:
- 审查肠道过度乙醇生产的机制.
- 阐明乙醇代谢在对肝脏和宿主代谢的病原性影响中的作用.
- 讨论针对肠道细菌乙醇生产的潜在治疗策略.
主要方法:
- 关于肠道微生物组,乙醇代谢和相关疾病的文献综述.
- 分析微生物乙醇生产背后的机制及其系统性影响.
- 综合当前关于治疗方法的知识.
主要成果:
- 肠道微生物组的组成通过代谢物对宿主代谢状态产生重大影响.
- 肠道微生物的内源性乙醇产量增加是肝病和代谢功能障碍的关键因素.
- 乙醇代谢在调解肠道衍生乙醇的有害影响方面发挥着重要作用.
结论:
- 过度的肠道乙醇生产是肝脏和代谢疾病的关键因素.
- 针对参与乙醇生产的肠道细菌提供了一个有希望的治疗途径.
- 对微生物向干预措施的进一步研究是代谢健康的必要.
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