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一个多光谱的3D活体有机体成像平台,用于光引导手术的查探头

Bernadette Jeremiasse^1,2, Ravian L van Ineveld^1,2, Veerle Bok^1,2

¹Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

EMBO molecular medicine

|June 3, 2024

概括

这项研究引入了一种新的多谱3D成像平台,使用器官来快速选分子探针以进行光导向手术. 这种方法模拟了患者瘤异质性,改善了完整瘤切除的探针选择.

科学领域:

手术瘤学手术瘤学
生物医学成像技术生物医学成像技术
翻译医学是一种翻译医学.

背景情况:

完全切除瘤至关重要,但具有挑战性.
使用分子探针的实时光引导手术 (FGS) 可以改善切除.
目前的临床前探针验证速度缓慢,并受到瘤异质性的限制.

研究的目的:

开发一个患者规模的平台,用于快速选多个分子探针.
通过使用有机体来建模患者瘤异质性和健康组织结合.
为了加快对FGS有效探测器的识别.

主要方法:

开发一个多光谱实时3D成像平台.
实施患者衍生瘤器官来模拟异质性.
使用有机体来评估分子探针对瘤和健康组织的结合.

主要成果:

该平台有效地模拟了患者瘤异质性的模型.
机器人技术准确地反映了体内探针结合的情况.
证明了对患者规模的探头查的能力.

结论:

开发的成像平台和器官模型为临床前探针评估提供了强大的工具.
这种方法加速了针对FGS的有针对性的探测器的开发.
通过增强瘤可视化,促进改善手术结果.

关键词:

乳腺癌乳腺癌乳腺癌光引导的手术光引导的手术多光谱3D成像技术神经母细胞瘤是一种神经母细胞瘤.来自患者的机器人

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