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[¹⁸F]FAPI为[¹⁸F]FDG PET/CT在I-IIIA阶段非小细胞肺癌中诊断淋巴结转移增加了价值:一项前性研究

Youcai Li¹, Yin Zhang², Zhihua Guo³

¹Department of Nuclear Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, China.

Cancer imaging : the official publication of the International Cancer Imaging Society

|June 3, 2024

概括

与FDG PET/CT相比,18标记的纤维细胞激活蛋白抑制剂 (FAPI) PET/CT在非小细胞肺癌 (NSCLC) 中检测淋巴结转移的特异性更高. 整合两种成像剂可以提高NSCLC分期的诊断准确性和临床决策.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射化学放射化学是指辐射化学.

背景情况:

淋巴结 (LN) 的分期对于非小细胞肺癌 (NSCLC) 治疗至关重要.
目前的成像方法在准确检测LN转移方面存在局限性.
纤维细胞激活蛋白抑制剂 (FAPI) 是一种新的成像追踪器.

研究的目的:

评估18 ([18F]) 标记的FAPI PET/CT对I-IIIA期NSCLC患者淋巴结转移的诊断价值.
为了比较[18F]FAPI PET/CT与[18F]氧糖 (FDG) PET/CT的疗效.
评估[18F]FDG和[18F]FAPI PET/CT整合对临床决策的影响.

主要方法:

对53名患有I-IIIA阶段NSCLC的患者进行前性研究,这些患者接受了彻底切除.
[18F]FDG和[18F]FAPI PET/CT在一周内进行.
通过手术和病理发现验证了LN分期;诊断性能进行了比较.

主要成果:

[18F]FAPI在LN转移检测方面的特异性明显高于[18F]FDG (P < 0.001).
线转移的危险因素包括高线风险类别,大线大小 (≥1.0厘米),没有化/高衰减,高线FDGSUVmax (≥10.1).
[18F]FDG和[18F]FAPI PET/CT的整合实现了N分期的最高准确度 (83.0%),并导致29名患者进行临床决策修订.

结论:

[18F]FAPI提供了有价值的额外信息,以减少在[18F]FDG PET/CT.CT后NSCLC的LN分期的诊断不确定性.
结合的[18F]FDG和[18F]FAPI PET/CT可在NSCLC管理中作出更精确的临床决策.

关键词:

FAPIAPI FAPIAPI 这是一个很好的方法.德国联邦航空公司 (FDG)淋巴结转移的发生是淋巴结转移.非小细胞肺癌是非小细胞肺癌.

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