花 morifolium 拉玛特提取物和益生菌组合通过调节肠道微生物群和PPARα亚细胞局部化来改善代谢障碍
Xinxin Gao1, Zhigang Zhu2, Yiyang Bao1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Chinese medicine
|June 3, 2024
概括
木和益生菌 (CP) 组合有效治疗非酒精性脂肪性肝病 (NAFLD) 并改善小鼠的葡萄糖代谢. CP调节肠道微生物群并激活PPARα,为代谢障碍提供潜在的治疗方法.
科学领域:
- 代谢性疾病研究研究.
- 传统中国医药 传统中国医药
- 肠道微生物组研究的研究
背景情况:
- 红 morifolium 拉马特和益生菌在代谢疾病中显示出个别益处.
- 它们对非酒精性脂肪性肝病 (NAFLD) 和葡萄糖代谢的联合作用的分子机制尚不清楚.
研究的目的:
- 阐明C. morifolium和益生菌组合 (CP) 的分子机制,以缓解高脂肪饮食 (HFD) 养小鼠的NAFLD和葡萄糖代谢失调.
主要方法:
- 通过肝脏组织学,血清分析和葡萄糖耐受性测试来评估CP的治疗效果.
- 使用16S rRNA测序和便微生物移植分析了肠道微生物群.
- 进行了肝脏转录组分析,验证了关键基因 (RT-qPCR,西方涂抹),并使用了PPARα淘汰赛小鼠.
主要成果:
- 在HFD小鼠中,CP降低了体重,肝硬化,改善了葡萄糖不耐受性和胰岛素抵抗性.
- CP缓解了HFD诱导的肠道失调,增强了葡萄糖代谢.
- 通过PPARα核定位调节肝脂代谢,通过降低Cidea/Cidec的调节和通过PPARα核定位调节CPT1α,激活脂肪酸氧化 (FAO).
结论:
- 通过调节肠道微生物群和PPARα亚细胞局部化,CP显示出低血糖和肝保护作用.
- CP具有作为代谢障碍治疗候选者的潜力.
相关概念视频
01:22Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
01:18Functions of the Gut Microbiota
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...