三糖糖 - - 腰与身高比率与冠心病之间的关联:一项基于人口的研究
Yangping Zhuang1,2,3, Yu Wang1,2,3, Peifen Sun1,2,3
1Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Lipids in health and disease
|June 3, 2024
概括
较高的甘油三-葡萄糖腰围与身高比率 (TyG-WHtR) 与美国人的冠心病风险增加有关. 这一指标有助于早期识别易患动脉样硬化的个体.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征研究 代谢综合征研究
- 生物标记分析 生物标记分析
背景情况:
- 三糖糖 (TyG) 指数和相关指标对于早期动脉样硬化风险分层至关重要.
- 现有的指标可能无法完全捕捉复杂的心血管风险.
- 这项研究研究了新的复合生物标志物,以改善风险评估.
研究的目的:
- 评估TyG腰围与身高比率 (TyG-WHtR) 与冠心病 (CHD) 风险之间的关联.
- 确定TyG-WHtR是否可以作为美国人口中CHD的预测标记.
- 探索这种关联中潜在的非线性关系和值效应.
主要方法:
- 对NHANES数据 (2011-2018) 的横截面分析.
- 多因素后勤回归模型来评估TyG-WHtR和CHD的关联.
- 对非线性相关性进行子组分析,相互作用测试,平滑曲线拟合和值效应分析.
主要成果:
- 在TyG-WHtR和冠心病风险之间发现了显著的正相关性.
- 没有观察到与性别,年龄,吸烟状况或癌症病史的显著相互作用.
- 确定了一个非线性关系,在TyG-WHtR = 0.36.3的拐点.
结论:
- 提升的TyG-WHtR水平与美国人口中冠状动脉心脏病的可能性更高有关.
- TyG-WHtR显示出作为一种有价值的工具,用于识别患有心血管疾病风险增加的个体的潜力.
- 进一步的研究可能会对临床风险分层协议的TyG-WHtR进行验证.
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