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Updated: Jun 24, 2025

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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针对G蛋白结合受体的药物的合理设计:从结构生物学角度来看

Polina A Khorn1, Aleksandra P Luginina1, Vladimir A Pospelov1

  • 1Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, 141701, Russia.

Biochemistry. Biokhimiia
|June 4, 2024
PubMed
概括

针对G蛋白结合受体 (GPCRs) 的基于结构的药物设计 (SBDD) 使用原子结构来找到向药物. 这篇评论详细介绍了GPCR药物发现的X射线衍射和冷EM等方法.

关键词:
在GPCR中,GPCR是指GPCR.冷电子显微镜的使用方法药物开发是药物的发展.宏分子晶体学 宏分子晶体学基于结构的药物设计.

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