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Updated: Jun 24, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

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Published on: February 20, 2018

8.9K

大麻素CB1受体的正异质调节增强了内分泌大麻素信号传递,并改变了ERK1/2酸化动力学

Hayley M Green1, Jamie J Manning1, Ian R Greig2

  • 1Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

British journal of pharmacology
|June 4, 2024
PubMed
概括

积极的全调节剂 (PAMs) 激活了没有内源配体的大麻素受体1 (CB1),可能会改变信号传输. 这些CB1全性激动剂在体内没有保留内分泌素的时空信号传递.

关键词:
在美国,我们有ABD123636在 GAT2299 中,我们可以看到:的 ZCZ01111 的情况.通过全osteric 调制.大麻素CB1受体是CB1受体.

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