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Updated: Jul 23, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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评估细胞因子释放综合征的药物相互作用潜力,使用基于生理学的药物动力学模型:teclistamabb的案例研究

Marie-Emilie Willemin1, Shun Xin Wang Lin2, Loeckie De Zwart1

  • 1Janssen Research & Development, Beerse, Belgium.

CPT: pharmacometrics & systems pharmacology
|June 4, 2024
PubMed
概括

德克利斯塔马布治疗可能会导致细胞因子释放综合征 (CRS),影响药物代谢. 药物动力学模型显示,在CRS期间的IL-6水平可能会对某些药物暴露产生适度影响,特别是在初始剂量时.

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