传统中医治疗后病毒性嗅觉功能障碍:系统性审查
Xiang-Yun Zou1,2, Xue-Han Liu1, Chun-Li Lu3
1Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Integrative medicine research
|June 4, 2024
概括
包括针在内的中国传统医学可能会改善长期COVID患者的病毒后嗅觉功能障碍 (PVOD). 然而,目前的证据有限且质量不佳,需要进一步严格的研究.
科学领域:
- 综合医学是一个整体医学.
- 基于证据的医学基于证据的医学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 后病毒性嗅觉功能障碍 (PVOD) 是长期COVID的常见症状,有效治疗方法有限.
- 传统中医 (TCM) 被提出作为嗅觉功能障碍的潜在治疗方法,但需要批判性证据评估.
- 本系统性审查评估了TCM干预PVOD的有效性和安全性.
研究的目的:
- 系统地审查和评估传统中医药 (TCM) 治疗病毒后嗅觉功能障碍 (PVOD) 的有效性和安全性.
- 综合来自对PVOD的TCM治疗的临床受控研究的证据.
- 确定对PVOD有希望的TCM干预措施,并指导未来的研究.
主要方法:
- 通过搜索八个数据库来确定的临床受控研究的系统审查.
- 使用Cochrane偏差风险工具和GRADE.使用的纳入研究的质量评估.
- 使用风险比率 (RR) 和平均差异 (MD) 的数据的元分析,使用95%的置信区间 (CI) 通过RevMan 5.4.1.1.
主要成果:
- 包括的研究包括6个RCT (545名参与者),2个非RCT (112名参与者) 和1个队列研究 (30名参与者);整体研究质量很低.
- 针 (8项研究) 和针注射 (3项研究) 是主要研究的TCM疗法.
- 五项RCT表明TCM,特别是针和针点注射对PVOD的潜在益处,而非RCT和队列研究显示无显著结果. 报告了轻微的不良事件.
结论:
- 有限的证据表明,针和针注射可以改善PVOD.
- 目前的证据质量不佳,这凸显了需要更多精心设计的试验的需要.
- 建议进一步进行以针为重点的高质量随机对照试验,以确认其对PVOD的益处.
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